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Diagnostic Test and Therapeutic Target for Sjogren's Syndrome

Sj?gren's syndrome is an autoimmune disease that attacks salivary glands resulting in chronic dry mouth and dry eyes.  Currently, there is no single diagnostic test to confirm the presence of Sj?gren's.  Physicians presently reach diagnosis after conducting a series of blood and functional tests for tear and salivary production. Diagnosis is further complicated as Sj?gren's symptoms frequently mimic those of other autoimmune diseases (e.g., lupus, rheumatoid arthritis, etc.) and is often overlooked as dryness associated with medications being taken by the patient.

Researchers at NIDCR have identified overexpression of a growth factor, bone morphogenetic protein 6 (BMP6), in patients with Sj?gren's.  By detecting BMP6 expression and/or activity, this invention potentially presents a singular confirmation to diagnose those suffering and those at risk for developing Sj?gren's.  BMP6 also presents a potential therapeutic target for Sj?gren's, a disease for which there is presently no cure.

Researchers have also discovered unique expression profiles for two other genes (XIST and MECP2) in male Sj?gren's patients.  Detecting aberrant expression and/or activity of these genes also offer a potential singular test for diagnosing Sj?gren's in male subjects.

Source: Diagnostic Test and Therapeutic Target for Sjogren's Syndrome

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