Author Topic: Science News: Alpha-Glucosidase Chaperones and Inhibitors for Treatment of Pompe Disease and Type 2 Diabetes  (Read 295 times)

MikeLigalig.com

  • FOUNDER
  • Webmaster
  • *****
  • Posts: 33284
  • Please use the share icons below
    • View Profile
    • Book Your Tickets on a Budget
Alpha-Glucosidase Chaperones and Inhibitors for Treatment of Pompe Disease and Type 2 Diabetes

Scientists at the NIH have discovered small molecules that can act as chaperones and correct the misfolding of mutated alpha-glucosidase enzyme.  Pompe disease is caused by deficiency or dysfunction of alpha-glucosidase.  The only FDA-approved treatment of Pompe disease is enzyme replacement, which is expensive and elicits an immune reaction in most patients that limits clinical utility.

NIH scientists also discovered small molecule inhibitors of alpha glucosidase enzyme.  Alpha glucosidase converts carbohydrates into monosaccharides.  Inhibition of this conversion is useful for type 2 diabetes.  Three FDA-approved inhibitors of alpha glucosidase exist but all have low efficacy:side effect ratios.

Source: Alpha-Glucosidase Chaperones and Inhibitors for Treatment of Pompe Disease and Type 2 Diabetes

Linkback: https://tubagbohol.mikeligalig.com/index.php?topic=65301.0
John 3:16-18 ESV
For God so loved the world, that he gave his only Son (Jesus Christ), that whoever believes in him should not perish but have eternal life. For God did not send his Son into the world to condemn the world, but in order that the world might be saved through him. Whoever believes in him is not condemned, but whoever does not believe is condemned already, because he has not believed in the name of the only Son of God.

👉 GET easy and FAST online loan at www.tala.com Philippines

Book tickets anywhere for planes, trains, boats, bus at www.12go.co

unionbank online loan application low interest, credit card, easy and fast approval

Tags: