Wala ba kaha intawon ni mental disability ang bata after sa surgery. Kaluoy tawon.
Hydrocephaly (ancephaly) during intrauterine growth is due to polyhydramnios of the placenta; which is a result of of neural tube defects and or Trisomy. The reason for the manifest of hydrocephaly is because there was insuficiency or deficiency of neural crest cells in migration of the forebrain, midbrain and hindbrain of the pharyngeal arches during embryonic development.
As a result of this, the fetus was unable to take in amniotic fluid, therefore it leads to Polyhadramnions (which is when the amniotic volume within the placenta is over 1500-2000ml) This is unatural since there should be around 800-1000 ml of volume in the placenta.
Co-indicative of hydrocephaly are:
a) Neural Tube Defects
b) Large amniotic fluid; Polyhydramnios
c) High alpha-feto protein within the mother's blood stream
One can see this as manifest in Ultrasound, or after amniocentesis.
Since polyhyadramnios and subesequent development of ancephaly (hydrocephaly) is the result of failure to or insufficient migration of neural crest cells--resulting in neural tube defect--by right, there will be neurological abnormalities in the fetus.
Patients who are born with said conditions have mental abilities that are under par compared to children who were born with no hyadramnio-complications.
The physiology of this is straightforward. Excess water in the cerebrospinal region will result in water entering sensitive regions; particularly the dura mater, arachnoid, subarachnoid space, pia mater and the cortical regions.
Any damage or defect in the cortical regions and surrounding glial cells will result in a manifest of neurological defects. To which will manifest upon the maturation of said child.
Yours,
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