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When using an anti-virus software to scan your disk, there are files in the hard disk where your operating system resides that should be excluded from the scanning process.

Instruction:
Do not scan the following files and folders. These files are not at risk of infection. If you scan these files, serious performance problems may occur because of file locking. Where a specific set of files is identified by name, exclude only those files instead of the whole folder. Sometimes, the whole folder must be excluded. Do not exclude any one of these based on the file name extension. For example, do not exclude all files that have a .dit extension. Microsoft has no control over other files that may use the same extensions as the following files.

•   Microsoft Windows Update or Automatic Update related files
•   The Windows Update or Automatic Update database file. This file is located in the following folder:
%windir%\SoftwareDistribution\Datastore
Exclude the Datastore.edb file.
•   The transaction log files. These files are located in the following folder:
%windir%\SoftwareDistribution\Datastore\Logs
Exclude the following files:
•   Edb*.log

Note
The wildcard character indicates that there may be several files.
•   Res1.log
•   Res2.log
•   Edb.chk
•   Tmp.edb

Source: Microsoft

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