NO AGE LIMIT
Cardiovascular diseases are the world's biggest age-related killers and de Grey says there is a long way to go on these though researchers have figured out the path to follow.
Heart diseases that cause heart failure, heart attacks and strokes are brought about by the accumulation of certain types of what de Grey calls "molecular garbage" -- byproducts of the body's metabolic processes -- which our bodies are not able to break down or excrete.
"The garbage accumulates inside the cell, and eventually it gets in the way of the cell's workings," he said.
De Grey is working with colleagues in the United States to identify enzymes in other species that can break down the garbage and clean out the cells -- and the aim then is to devise genetic therapies to give this capability to humans.
"If we could do that in the case of certain modified forms of cholesterol which accumulate in cells of the artery wall, then we simply would not get cardiovascular disease," he said.
De Grey is reluctant to make firm predictions about how long people will be able to live in future, but he does say that with each major advance in longevity, scientists will buy more time to make yet more scientific progress.
In his view, this means that the first person who will live to 1,000 is likely to be born less than 20 years after the first person to reach 150.
"I call it longevity escape velocity -- where we have a sufficiently comprehensive panel of therapies to enable us to push back the ill health of old age faster than time is passing. And that way, we buy ourselves enough time to develop more therapies further as time goes on," he said.
"What we can actually predict in terms of how long people will live is absolutely nothing, because it will be determined by the risk of death from other causes like accidents," he said.
"But there really shouldn't be any limit imposed by how long ago you were born. The whole point of maintenance is that it works indefinitely." --
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