Interesting desease. I am still confused what is the difference between a desease and abnormality. If ALS is a genetic abnormality, then it is not a desease and can not be treated. Abnormality in a gene is something natural with no treatment, but we can only re-divert its fate to make the person better. Or maybe to eliminate the problem genes through breeding techniques so this can not be passed to the next generation. I remembered one of my neighbors said that she will choose the bride of his son because they have some sort of blood abnormalities. Incase her son chooses the wrong pair, her grandson will surely suffer from a rare form of anemia.
Also, I have seen on TV a documentary about a tribe with defective gene which causes thier feet to branch out, thus they are called the "ostrich feet tribe". A defective gene was identified and it was nutralized through selective breeding. So for some period of time, they can not choose their true love.
How is Lou Gehrig's disease compared to Alzheimers desease. Can ALS be treated with the controversial stem cell? By the way, there is now new and easy way to collect stem cell from the placenta instead of the aborted fetus which became controversial during George Bush time.
How about gene therapy, I am also curious, it says it can make you young or change your race from asian to caucasian, is it true?
Mr. Ferniz, you raise scintillating questions.
A)Disease in its basic sense is an abnormal condition of an organism that impairs bodily functions, which comes with physical symptoms that leads to its identification and thus possible modes of treatment are prescribed by the physician and/or a surgical procedure is implemented to alleviate the certain condition.
Genetic abnormality is a result of gene-sequential mutanogensis, meaning that there was an error in the protein synthesis, either it be alteration in the production of proteins in the ribosome, some kind of malfunction of the RNA Polymerase I, II, III to bind to the open promoter complex thus leads to a ceasure of helicasization, kinasization. When this occurs, there is no translation of the gene, there is no elongation of the gene, and if there is no translation or elongation, then there is no transcription. We have abortive transcription. If we have abortive transcription, then certain genetic sequences that are responsible for proper formation of tissue types (endothelium, cardiac, smooth muscle, rough muscle, neural, genital, osteolithic (bone tissue), occipital (eye) etc) will not manifest. With these tissue-specific gene sequences inhibited, then as a result diseases and physical degeneracy will manifest outright.
Every disease, physical and mental degeneracy is a result of genetic failure. In example, for those who suffer Alzheimer's. Alzheimer's disease is a result of neural degeneracy in which our neural synapse is unable to transmit information into the cortical apex of the brain and allow retrieval. As a result of this, we have inability to remember, inability to integrate the present to the past. Two abnormal structures called plaques and tangles are prime suspects in damaging and killing nerve cells. Plaques build up between nerve cells. They contain deposits of a protein fragment called beta-amyloid. Tangles form inside dying cells. Though most people develop some plaques and tangles as they age, those with Alzheimer’s tend to develop far more. The plaques and tangles tend to form in a predictable pattern, beginning in areas important in learning and memory and then spreading to other regions.
Why does Alzheimer's manifest in the elderly? It is because of genetic degeneracy. As we age, the wear and tear of genetic transcription damages the RNA Polymerase I, II, III, and as we age site-specific mutanogenisis is common due to the protein inhibition, weakness of protein folding. This simple error translates into a gigantic error in the visceral-organismal level. Proper gene sequences that are responsible for creating the axon and the myelin sheath (which is the protein coating that covers the axon--allowing neural messages to be sent down and up the neural interface) will be damaged, and or unable to repair itself. Another genetic mutanogenisis is that the wrong TAFII (Tata promoter-associated factor) will bind to the wrong protein activator, or a lead to the truncation of a particular DNA plasmid nucleosome. When this happens, we have the wrong sequences binding, and mutation is manifest over 10 million fold. Thus we have the formation of plagues and tangles. Thus Alzheimer's is present. It is mostly an age-specific neural degeneracy (abnormality/disease) in that it is a result of genetic impudence--a result of age.
Diseases, therefore, manifests as a result of genetic mutanogensis. Every disease known to man is a result of genetic mutanogensis. Diabetes is a disease in the American Medical Association, but we all known that it is a result of the body's inability to produce Insulin, which is regulated by the Insulin gene. What happens is that there is a repressor that inhibits the insulin gene from expressing itself in the open promoter complex. When this happens, there is no elongation, no translation, no transcription. Thus, no insulin gene being expressed in the DNA chromatin, and DNA structure. Therefore we have the body's inability to produce Insulin, therefore we have diabetes.
Chemical therapy is present in that we have diabetic medical that provides insulin to the body.
Every disease is genetically-linked. The quicker we locate the peroxidase sequence-specific areas of a disease, the faster we can find a way to develop drugs and models that can over-express that gene or create an anti-repressor that can nullify the repression in mutanogenesis.
B)Amytrophic Lateral Sclerosis can be properly treated by chemical therapy. As we speak, there are scientists researching in the creation of repressors that can nullify the ability of the mutanogensis that resulted in the production of Alsin. And since the Alsin gene is responsible for the production of ALS2, its inhibition and inability to express itself in the DNA chromatid structure of the DNA strand, will allow the body's ability to developing properly. However, if there is no inhibition of the Alsin gene, then ALS2 will be transcribed and thus we have manifestation of Amytrophic Lateral Sclerosis.
The Alsin gene, if mutated, will allow this. There are studies, as we speak, that is indentifying the cause of this mutation of the Alsin gene.
Unfortunately, Mr. Ferniz, drug formation and creation takes years. Research is a conservative process that undergoes countless trials (animals) before making it into human trials. And even if there is a positive confidence in treatment, the drug companies decide in its marketing ability. Cost, is always a factor.
Right now, the only mode of treatment are pain killers, bed side care and tertiary prescriptions that targets bacterial activity in ALS patients (who tend to be more immunosuppressed than non-ALS patients).
Every mode of disease is understood in pure sample. Every treatment created by man for diseases has been a product of stem cell harvesting. The reason for this, Mr. Ferniz, is that stem cells are non-specific cells. Thereby it can develop into any tissue, if placed in that area. If we take a stem cell and place it on top of a damaged cardiac tissue, the stem cell (because of God's brilliance) will actually mold itself and transform itself into a cardiac muscle cell and begin to replicate. They will then repair the damaged heart tissue. If stem cell is placed near a damaged neural tissue, the stem cell will mold itself and transform itself into a precious neural tissue (neural tissue does not replicate btw, that is why any damage on neural tissue is irreversible without stem cell intervention/utilization) and repair itself. Stem cells are uni-specific. They will become whatever their surroundings are.
This is the reason why they are so imperative to medical and scientific research. Stem cells are pure and unadulterated. Yes, we can take stem cell samples from fetuses, however one needs to understand that if we do that there is a high risk of killing the fetus since the stem cells in the fetus are molding itself into either neural tissue, cardiac tissue, osteolithic tissue (bone), occipital tissue (eye), occular tissue (ear), etc. That is why no parent of mother is willing to allow that.
C)Caucasians, Mongoloids and Negroids are all of the same genus: Homo sapiens sapiens. Any differences we have are primarily phenotypic and a result of evolution and of the climactic extremes the said races lived in. Skin tone differences are merely mutations in the endothelium in that there are overactive melnocytes, which are responsible for skin tone and color. Negroids lived in the central plain near the equalitorial range, hence they were bombarded with solar rays, to survive in such harsh and hot climates, they developed overactive melanocytes and thus are dark. Their hair is also kinky as an evolutionary change to repel heat. Caucasoids, who lived above the equalitorial range and were subjected to significantly less solar ray developed less melanocytes thus their skin tone are light. Their eye color differentiation is nothing more than genetic mutation and recessivity. The dominant human trait is brown eyes. This is seen in negroid and mongoloids. Mongoloids developed differently due to the harsh weather of the Pleistocene. Mongoloids came from the Siberian region, where snow was constant and sun irregular. That is why the eye fold of Mongoloids are prominent, the short stature is a result of lack of sun, lack of food in the Siberian region. Lack of calcium intake.
All races are inter-breedable; and thus all similar. Any differences we have are only phenotypic and slight genetic differences. Hypothetically, Mr. Ferniz, one can use gene therapy to change the phenotype of a fetus while developing.
In my opinion that is unnecessary and unnatural for the parents to do. I believe in gene richness. Any mixing of children due to the inter-racial marriage of both parents combines the genotypes. Thereby making the offspring genetically superior to both parents. As they have the best of both worlds.
I hope I answered your questions appropriately, sir.
Linkback:
https://tubagbohol.mikeligalig.com/index.php?topic=12009.0