In the 'worst-case scenario' simulation, M31 slams into the Milky Way head-on and the stars are all scattered into orbits,' said team member Gurtina Besla in a statement.
The Andromeda is plowing toward Earth's galaxy at roughly 250,000 miles per hour.
That rate is the equivalent of traveling from Earth to the moon in an hour.
Astronomers also believe a third, smaller galaxy called the Triangulum will also be a part of the collision and could join the Milky Way and Andromeda mash-up.
It previously had been difficult to determine whether the two galaxies would slam into each other.
Members of the NASA Hubble Space Telescope team, however, were able to make certain that the two will crash with exact views of Andromeda's sideways motion.
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