Mandatory information for Surgical interns, anesthesiology intern, surgical nurses, nurse anesthetists etc.CNS drugs must be lipid soluble (cross the bbb- blood brain barrier) or be actively transported
Drugs with decreased solubility in blood = rapid induction and recovery times.
Drugs with increased solubility in blood = increased potency = 1 / MAC
where MAC = Minimal alveolar concentration
Examples: N20 has low blood and lipid solubility, and thus fast induction and low potency. Halothane , in contrast, has increased lipid and blood solubility, and thus high potency and slow induction.
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