Methods of Treating and Preventing Renal Cancer using Dimethane Sulfonate Compounds
This invention describes a series of dimethane sulfonate compounds based on NSC 281612 and compositions comprising a pharmaceutically-acceptable carrier and a compound, or a salt, that are suitable for the treatment of renal cancer. The anti-tumor activity of NSC 281612 has been established in vivo against human renal tumor xenografts in mice. Suitable dosing and administration schedules for treatment of renal tumors have also been determined in this study.
Currently only a few small molecule inhibitors are effective in patients with renal cell carcinoma. Approximately 30,000 patients per year are diagnosed with this disease but many of them are untreatable because of intrinsic drug resistance, and efficient drug transport and detoxification mechanisms.
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