Author Topic: Modified Response to Injury Hypothesis of Atherosclerosis Development  (Read 593 times)

MikeLigalig.com

  • FOUNDER
  • Webmaster
  • *****
  • Posts: 33285
  • Please use the share icons below
    • View Profile
    • Book Your Tickets on a Budget
The Modified Response to Injury Hypothesis of Atherosclerosis Development

The modified response to injury hypothesis, as it pertains to the development of atherosclerosis, proposes the following tenets: (1) endothelial injury results in growth factor secretion; (2) the local hemodynamic environment (low shear and oscillating shear) facilitates local injury and particle transfer; (3) circulating monocytes attach to the damaged endothelium; (4) subendothelial migration of monocytes may lead to fatty streak formation and further release of growth factors such as PDGF; (5) fatty streaks may then be converted to fibrous plaques via release of growth factors from macrophages, endothelial cells, or both; (6) macrophages may stimulate or injure the overlying endothelium, thus endothelial cell loss leads to platelet deposition; (7) platelet deposition leads to the release of growth factors and mitogenic factors for smooth muscle cells; and ( 8
) some of the smooth muscle cells in the proliferative lesion itself may form and secrete growth factors.

Linkback: https://tubagbohol.mikeligalig.com/index.php?topic=68968.0
John 3:16-18 ESV
For God so loved the world, that he gave his only Son (Jesus Christ), that whoever believes in him should not perish but have eternal life. For God did not send his Son into the world to condemn the world, but in order that the world might be saved through him. Whoever believes in him is not condemned, but whoever does not believe is condemned already, because he has not believed in the name of the only Son of God.

👉 GET easy and FAST online loan at www.tala.com Philippines

Book tickets anywhere for planes, trains, boats, bus at www.12go.co

unionbank online loan application low interest, credit card, easy and fast approval

Tags: