Author Topic: Consistent And Successful Islet Isolations Offer Diabetes Hope  (Read 773 times)

Lorenzo

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Consistent And Successful Islet Isolations Offer Diabetes Hope



A team of researchers from several collaborating Baylor University research centers and from Japan's Okayama Graduate School of Medicine have found a way to more consistently isolate pancreatic islet cells from brain dead donors using ductal injection (DI), a process that immediately cools donor islet cells at the injection site. The more successful islet isolation process resulted in the three type 1-diabetes patients, who received islet cell transplants, becoming insulin independent.

Their study is published in issue 19(3) of Cell Transplantation and it is now freely available on-line at http://www.ingentaconnect.com/content/cog/ct/.

"Inconsistent islet isolation is one of the important issues in clinical islet transplantation," said Dr. Shinichi Matsumoto, the research team's lead author. "Failure of donor islet isolation often results from the loss of the donor pancreas. Our simple modification of the retrieval process appears valuable for assuring greater success in islet transplantation."

Ductal injection is a procedure that modifies the islet isolation process using a cooling solution on the pancreatic islet cells derived from brain-dead donors. The cooling solution, applied at the donor's pancreatic ductal site, aids the viability of the islet cells.

The team successfully isolated islet cells in the DI group seven times while only three out of eight islet cell groups were isolated in the nonductal injection group. When islets from the DI group were transplanted into three type 1 diabetic patients, all three became insulin independent.

"DI significantly improved the quantity and quality of isolated islets and resulted in a high success rate of clinical islet transplantation," said Dr. Matsumoto.

According to the research team, a fifty percent success rate for clinical islet isolation has been standard; they were able to achieve a better than 80 percent success rate using DI.

The team reported that there were no significant demographic or clinical differences in the two patient groups receiving islet transplants, nor were there significant differences in the donated pancreata. All donor pancreata were preserved for less than six hours. Each patient received two islet preparations.

"In the DI group, the fasting blood glucose of all three patients improved after a single islet transplantation, and improved further after the second transplantation," commented Dr. Matsumoto. "None of these patients experienced subsequent hypoglycemia, and all three became insulin independent."

The team had recently shown that the DI process was successful in animal models because DI prevented tissue and cell death, suggesting that DI improved the quality and quantity of the isolated islet cells destined for transplantation.

"The number of islets isolated from donor pancreata continues to be quite variable and many times are not sufficient for clinical transplantation" said Dr. Rodolfo Alejandro, section editor for Cell Transplantation and Professor of Medicine at the University of Miami Miller School of Medicine. "This paper describes a novel approach to improve islet isolation yields. These are promising results that need to be confirmed in a randomized concurrent protocol".



http://www.medicalnewstoday.com/articles/190914.php

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Lorenzo

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Re: Consistent And Successful Islet Isolations Offer Diabetes Hope
« Reply #1 on: June 08, 2010, 10:53:21 AM »
I would say within 1 decade time, we would have already provided proper containment procedures to prevent diabetes from progressing into neuropathic pathologies. That is, if it is detected in time and if patient responds to therapeutic goals.

This is a success for medicine; the research arm; and clinical trials.

Excellent!

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chicogon

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Re: Consistent And Successful Islet Isolations Offer Diabetes Hope
« Reply #2 on: June 08, 2010, 01:15:49 PM »
I would say within 1 decade time, we would have already provided proper containment procedures to prevent diabetes from progressing into neuropathic pathologies. That is, if it is detected in time and if patient responds to therapeutic goals.

This is a success for medicine; the research arm; and clinical trials.

Excellent!

Unsa ning neuropathic pathology Enz? Kanang naay mag dagan2x ok-ok (feeling) sa imong likod or kaunoran? Isn't that caused mostly by medicines parehas atong naay mga parkinson disease?


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Lorenzo

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Re: Consistent And Successful Islet Isolations Offer Diabetes Hope
« Reply #3 on: June 08, 2010, 09:53:30 PM »
Unsa ning neuropathic pathology Enz? Kanang naay mag dagan2x ok-ok (feeling) sa imong likod or kaunoran? Isn't that caused mostly by medicines parehas atong naay mga parkinson disease?


Hi Father,


Peripheral neuropathy is the numbing of our distal limbs (arms, legs, toes) because of the diabetic condition. When a patient has diabetes, they cannot feel pain in their distal ligaments, and thus, implement trauma to their lower ligaments because they do not feel pain, and they do this not on purpose. Trauma can be like running alot and putting pressure and damage on their foot, toes because they do not feel pain. As a result of this, most diabetics usually have plantarfasciaitis , or plantar trauma, and have diabetic foot diseases.

Peripheral neuropathy is basically when the plexus of nerves distal to the thoracodorsal core becomes numbed and its firing mechanism is slowed because of the diabetes.

Parkinsonian-like diseases have a different mechanism of action as Diabetic neuropathy (peripheral neuropathy) because Parkinsons is related to an abnormally decreased level of Dopamine hormones, due to the damage of the substantial nigra and the niagrostriatal tract of the brain. This leads to an abnormally low level of domapine hormone and thus explains the movement disorderes seen, clinically, in Parkinsonian disease.


How we treat both diseases differ.

Diabetes and peripheral neuropathy is treated by maintaining insulin levels and treating the foot,leg,ankle.
Parkinsons is treated by taking synthetic forms of dopamine so as to increase the abormally low dopamine levels, but at the same time making sure that the dopamine levels are not abnormally high, because too much dopamine leads to Pyschosis (a mental disorder with abnormally high dopamine level).

Again, there is always the emphasis of stability, moderation and homeostasis (equilibrium) in the body.

The way GOD IN THE MOST HIGH designed our body, he made it that everything works in a system and that everything is sensitive, and requires equilibrium. Deviation of that equilibrium leads to pathology. And pathology--is the basis of disease formation.



Hope that helps, Father.



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chicogon

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Re: Consistent And Successful Islet Isolations Offer Diabetes Hope
« Reply #4 on: June 09, 2010, 02:53:14 AM »
Thanks Enz. Yes info like this helps.

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