Author Topic: CHIMERA: The beauty of genetic manipulation  (Read 667 times)

Lorenzo

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CHIMERA: The beauty of genetic manipulation
« on: May 26, 2008, 02:35:09 AM »
A CHIMERA is an animal that has two or more different populations of genetically distinct cells that originated in different zygotes; if the different cells emerged from the same zygote, it is called a mosaicism. Chimerism is rare in human beings: there have been only about 40 reported cases.

Chimeras are formed from four parent cells (two fertilized eggs or early embryos fuse together) or from three parent cells (a fertilized egg is fused with an unfertilized egg or a fertilized egg is fused with an extra sperm). Each population of cells keeps its own character and the resulting animal is a mixture of mis-matched parts. An analogy is two jigsaw puzzles cut using an identical cutter, but with different pictures. A single puzzle can be made out of the mis-matched parts, but the completed puzzle will show parts of both pictures.

This condition is either inherited, or it is acquired through the infusion of allogeneic hematopoietic cells during transplantation or transfusion. In fraternal twins, chimerism occurs by means of blood-vessel anastomoses. The likelihood of a child being a chimera is increased if the child is created via in vitro fertilization. Chimeras can often breed, but the fertility and type of offspring depends on which cell line gave rise to the ovaries or testes.


Genetic view of Chimera. Two distinct DNAs within one organism. Normally an organism will only have 1 set of DNA, but Chimeras have 2. Two people within one body.


Chimerized cells, via Electron microscope. Absolutely Beautiful.

Chimeras is a result of genetic degeneracy during transcription and replication process in the molecular level. However, instead of dying, the organism succeeds and survives. It is an example of evolutionary multipolarity. Its transparency in research has revealed alot about human development over the eons.
Absolutely beautiful.

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