Blue family

[hubag bohol]

[hubag bohol]

By DAILY MAIL REPORTER
UPDATED: 18:03 GMT, 16 February 2012


Talk about blue in the face... Extraordinary story of Appalachia's 'Blue Family' whose bodies were discoloured after generations of inbreeding

--Isolated family in Kentucky started producing blue children in 1800s

--French orphan Martin Fugate married pale American Elizabeth Smith

--Had seven children, four were blue; they intermarried with local family

--Genetic mutation reduces individual’s ability to carry oxygen in blood

--Intermarriage led to 'pure' gene pool which often met 'met-H' gene

[hubag bohol]

In the Appalachian Mountains rests a medical oddity so unusual that it at first seems a massive hoax.

Dating back to the early 1800s, an isolated family in eastern Kentucky - who can trace their roots back to a French orphan - started producing children who were blue.

As a result of a coincidental meeting of recessive genes, intermarriage and inbreeding, members of the Fugate family were born with a rare condition that made them visibly discoloured.

[Lollapalooza]

mura'g Smurfs...

[hubag bohol]

Feeling blue: Due to inbreeding and inter-marriage, a rural family developed a rare skin discolouration'


The mystery behind the astonishing picture of the Fugates, which has been baffling people for years, appears to have finally been solved.

It began when Martin Fugate, a French orphan, settled on the banks of eastern Kentucky's Troublesome Creek to claim a land grant in the early 19th century.

[hubag bohol]

mura'g Smurfs...

Mao jud. Mora pud og si Krishna...

[hubag bohol]

He married a red-haired American named Elizabeth Smith - who had a very pale complexion - and their union formed a genetic mutation that resulted in their descendants being born with blue skin.

Looking at the portrait, they appear to have been either Photoshopped or made up to mimic characters from children's cartoon The Smurfs, but science proves that the condition is in fact real.

[hubag bohol]

Rural: The Fugates lived in an isolated part of eastern Kentucky and had little opportunity to mix with others

[Lollapalooza]

sila gyud ang original na may DUGONG BUGHAW.... wala pod naliwat sa mga apo ani?

[hubag bohol]

sila gyud ang original na may DUGONG BUGHAW.... wala pod naliwat sa mga apo ani?

Naay motumaw...



Methaemoglobinaemia (commonly known as met-H) is a recessive gene (shown by the small r) so only produces 'blue' people in very rare circumstances

[hubag bohol]

Methemoglobinemia is a blood disorder in which an abnormal amount of methemoglobin -- a form of hemoglobin -- is produced. Hemoglobin is the molecule in red blood cells that distributes oxygen to the body. Methemoglobin cannot release oxygen.

In methemoglobinemia, the hemoglobin is unable to release oxygen effectively to body tissues. -- http://www.nlm.nih.gov/

[Lollapalooza]

Naay motumaw...



Methaemoglobinaemia (commonly known as met-H) is a recessive gene (shown by the small r) so only produces 'blue' people in very rare circumstances

time sa mura'g naglisud ko sabot ani.. .asa na to si Doc Bran..

[hubag bohol]

Relations: A photo of Lorenzo 'Blue Anze' Dow Fugate and Eleanor Fugate, taken around 1915

[hubag bohol]

time sa mura'g naglisud ko sabot ani.. .asa na to si Doc Bran..

He he, mantinir lang una ta ani nga explanation from the Daily Mail article:


Called methaemoglobinaemia (commonly known as met-H), the condition reduces the individual’s ability to carry oxygen in their blood. As a result, their blood is darker than the colour typically found running through people’s veins.

Because the Fugate family lived in such an isolated part of the Kentucky, they intermarried with a neighbouring family for generations which led to a relatively ‘pure’ gene pool where the met-H gene appeared much more frequently.

The family was first discovered in 1958 when one of the blue men, Luke Combs, who was a descendant of another branch of the Fugate family, took his white wife to the University of Kentucky Hospital and doctors paid more attention to him than his wife.

‘Luke was just as blue as Lake Louise on a cool summer day,’ doctor Charles H. Behlen II told the Tri-City Herald in 1974.

Aside from the stark discoloration of the carrier’s skin, there are no serious problems associated with the disease.

In 1980, a counter-intuitive solution was discovered where the blue person drinks a chemical-filled solution that is itself blue. This then turns the carrier’s blood into a ‘normal’ red hue which is then reflected in a change in skin tone.

Because of the dispersion of fluids, the solution only lasts for about a day so the carrier would have to drink a serving every day.

[Lollapalooza]

sa ato pa, wala na nagpadayon ilang bloodline kay napangitaan ug solution..

[hubag bohol]

As eastern Kentucky has become vastly more populated than the early 19th century, and as more genes are married into the Fugate family tree, there were far fewer children born with the condition.

That said, the recessive met-H gene lingers to this day, but it is statistically insignificant now.

‘They weren’t sick; it was just the way they look,’ said nurse Ruth Pendergrass in the Tri-City Herald article. 'They’re normal people - they’re good people.’ -- http://www.dailymail.co.uk/

[islander]

nganong mahibung man sila nga naa man ganiy daghang mga tawo nga tapol.  naa poy green.  unsa man diay nang ginganlan ug olive-skinned.  naay yellow sa china.  sows ba uroy.  ang angay kahibudngan kun ang panit checkered o striped o morag star-spangled banner ba kaha.