One Eye Is Blue, The Other Is Brown: A Mysterious Disease

[slackware]

One Eye Is Blue, The Other Is Brown: A Mysterious Disease - Heterochromia iridis
By: Stefan Anitei, Science Editor - Softpedia


Human heterochromia

Do you know what David Bowie and many Border Collie dogs have in common? It is heterochromia, a condition in which the eyes are colored differently.

As heterochromia can also be encountered for hair or skin, the ocular one is called heterochromia iridis or heterochromia iridium. The iris can have a different hue
from the other (complete heterochromia), or only a part of it differs from the remainder (partial heterochromia or sectoral heterochromia).

The color differences are determined by variations of the melanin pigment within an iris, due to genetic causes (like Horner's syndrome), mosaicism (mutation occurred during the development), disease or injury. When hereditary, heterochromia is a dominant trait. The affected iris can be hyperpigmented (hyperchromic) or hypopigmented (hypochromic), usually connected with hyperplasia (overgrowth) of the iris tissues or hypoplasia (less tissue).

The melanocytes (melanin contains cells of the iris) do not synthesize in the absence of innervations, and unilateral congenital or birth injury of these nerves induces heterochromia.

Iris colobomata (gaps in the iris) produces heterochromia, the darker iris being the one with coloboma.

Microphthalmia (small eyes), determined by mutation or fetal alcohol syndrome, can induce heterochromia. Neoplasms (benign tumors) in the iris can change the color of just one eye (e.g. Lisch nodules). Melanosis (the abnormal increase of melanocytes) and port-wine stains make one eye darker.


Heterochromia in puppies of Border Collie

Individuals suffering from albinism, piebaldism (partial albinism), incontinentia pigmenti (hypopigmentation) are prone to heterochromia. Accidental iron deposits in the eye, iritis (iris infection) and certain eyedrops can induce heterochromia.

Heterochromia is much more common in mammals than in humans, particularly in some breeds, like cats (with one copper/orange eye and one blue eye), dogs, horses ("wall-eyed" with one brown and one white/blue eye), and water buffalo. In cats, the most prone are the Japanese Bobtails, Turkish Vans and the Turkish Angora while in dogs the Siberian Huskies, Australian Shepherds, and Border Collies.

Partial or sectoral heterochromia is a lot less frequent than total heterochromia and it’s usually associated with autosomally genetic diseases like Hirschsprung's and the Waardenburg syndrome.

[Happy]

unsa mana bad or good?

[slackware]

depende...

[C2H4]

Kate Bosworth (Orlando Bloom's ex and star of the awesome movie, Blue Crush) has this condition too. She has one blue eye and one brown eye.

[ms da binsi]

o really?? ay ex na sha??


it's my turn na ni Orlando???


haaay i like that gyud.. (pantasyera)

mao gyud na sha akong gi wish makita sa LA sa una...

ning balhin nalang ko wa gyud ko kakita...

[hazel]

Kate Bosworth (Orlando Bloom's ex and star of the awesome movie, Blue Crush) has this condition too. She has one blue eye and one brown eye.

Funny! I just saw the movie last Sunday but I didn't notice that the eye colors were different.

[slackware]

nag contact lens to siya

[C2H4]

Funny! I just saw the movie last Sunday but I didn't notice that the eye colors were different.

You can find close-up pics of her in the internet nga ma klaro iyang mata, Miss Ginger.

That is one of the things Orlando loved about her.

[C2H4]

o really?? ay ex na sha??


it's my turn na ni Orlando???


haaay i like that gyud.. (pantasyera)

mao gyud na sha akong gi wish makita sa LA sa una...

ning balhin nalang ko wa gyud ko kakita...

A girl I know was eating at a small resto in LA, and at the next table, na notice daw niya nga naay lalake nag inusara ug kaon, he was wearing a cap. She approached him and said that he looked a lot like Orlando Bloom, he just smiled and said hi. Pagka dungog daw niya sa voice, that's when she realized it was really him! Nag estorya2x pa daw sila kadiyot, she got a pic and an autograph. He was very nice kuno, very down-to-earth.

AyyyYyy! Grabe na crush jud ko anang Orlando sa una pa nga Legolas na siya sa Lord of the Rings, Miss Belle.

[Lorenzo]

The phenotypic effects of an individual's eyes are phylogenetic on that basis, eye color is determined by the three loci EYCL1, EYCL2, and EYCL3. Any combination of this results in brown, green, blue, and or admixtures of the color scheme. Unfortunately, there are genetic anomolies which manifests in different iris color, due to an unstable melanin base within the iris or inactive melanocytes. The condtion is called heterocrhomia. Its caused by genetic disease such as chimerism and waardenburg syndrome.

[Lorenzo]

unsa mana bad or good?

Well there are negative medical implications with excessively light iris color. Medical research by Johns Hopkins University and Georgetown University have already found out that those with lighter iris scheme have a substantially higher age-related macular degeneration than those with darker iris schemes. People with lighter iris schemes are susceptible to uveal damage, and those with heterochromia are primarily at risk because their lighter eye color have substantial amounts of inactive melanocytes, which places them in greater risk of ARMD than those with naturally light iris schemes on two eyes.

[Happy]

Salamat kaayo sa info dong Bran.

Sa una abi nako ug lain lain color sa mata kay basin ang usa ka mata liwat sa ancestor sa pikas nya ang usa pud ka color liwat pud sa pikas side

[hazel]

Salamat kaayo sa info dong Bran.

Sa una abi nako ug lain lain color sa mata kay basin ang usa ka mata liwat sa ancestor sa pikas nya ang usa pud ka color liwat pud sa pikas side

hahahhahahaha Happy. Maayo nalang ka naa'y explanation.

[Happy]

Maayo lagi intawon kay nalamdagan ang akong hunahuna