Death Toll Estimate: 100 Million

When Christopher Columbus, John Cabot and other explorers in the 15th century found a new continent, it must’ve seemed like the dawn of a new age. Here was a new paradise that adventurous Europeans could call their new home. There was, however, one problem: this land already had an indigenous population.
Over the following centuries, the seafaring Europeans brought vast death tolls to what is now referred to as North and South America. Although war and invasion can account for a hefty chunk of these casualties, it was the natives’ lack of immunity to European diseases that caused the most deaths. Some estimates state that 80% of the Native American population died as a result of contact with Europeans. --
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