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excerpt: from Tessa Salazar's article on PDI

Coffee overstimulation

It has been said that there’s a heavy price to be paid for stimulation. A Norwegian research project known as the Tromso heart study assessed 143,000 men and women and found a significant increase in depression in women who were heavy coffee drinkers (but not in men who drank similar amounts).

Women who drank excessive amounts of coffee also had more problems coping with stress. Nedley cited various studies linking caffeine and impaired brain functions. The effects may include psychiatric illnesses, impaired physical and mental performance, and may interfere with sleep.