In this free webinar, the featured speaker will present a comparison of digital PCR (dPCR) and quantitative (qPCR), including advantages and disadvantages of each technique. The webinar will explore why partitioning increases the variant fraction in the sample, and how dPCR excels in the quantification of low abundant genes or small differences. Best practices for limit of detection (LOD) and limit of quantification (LOQ) determination will also be presented, along with elements of a validation plan for a clinical trial study.
TORONTO (PRWEB) NOVEMBER 19, 2020
Since becoming commercially available in 2011, digital PCR (dPCR) has been gaining in popularity as it enables nucleic acid quantification with superior accuracy and precision compared to quantitative PCR (qPCR).
With data acquisition taking place at the end of the reaction, and since absolute concentrations can be determined, data can be easily interpreted and compared across different samples and experiments, especially in a clinical setting. Additionally, dPCR doesn’t suffer from the inherent complications of qPCR that result from the requirement of a standard curve, and excels in the quantification of low abundant genes or small differences.
This webinar will describe the intrinsic potential of droplet digital (ddPCR) in clinical research for three different applications:
Rare variant analysis in plasma samples
Small changes in alternative splicing
CAR-T studies
During the talk, the featured speaker will analyze the rationale for dPCR selection and present relevant case studies.
Join Jan Hellemans, PhD, Co-founder and Chief Technology Officer, Biogazelle, in a live webinar on Tuesday, November 24, 2020 at 10am EST (3pm GMT/UK).
For more information, or to register for this event, visit Applications of Digital PCR in Clinical Research.
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