MikeLigalig.com

Xeljanz is approved for use by patients not helped by methotrexate, the usual first treatment for RA. It's a pill taken twice a day.

Xeljanz is a type of drug called a Janus kinase or JAK inhibitor. Blocking JAK mutes the inflammation responses responsible for RA.

"Xeljanz provides a new treatment option for adults suffering from the debilitating disease of RA who have had a poor response to methotrexate," says Badrul Chowdhury, MD, PhD, the FDA's head of pulmonary, allergy, and rheumatology products.

Some 70% of RA patients eventually stop responding to methotrexate. Some 1.5 million Americans suffer from RA.

In clinical trials, patients taking Xeljanz had better physical functioning than patients taking an inactive placebo pill. But because it inhibits immune responses, Xeljanz adds to a person's risk of serious infections, cancers, and lymphoma. The drug will carry a "black box" warning about these risks.

People taking Xeljanz also had higher cholesterol levels, lower blood counts, and increased liver enzyme levels. Prescriptions will come with a medication guide carrying important safety information and a plan for informing health care providers about the drug's serious risks.

More common side effects associated with Xeljanz are upper respiratory tract infections, headache, diarrhea, and inflammation of the nasal passage and the upper part of the throat.

Because Xeljanz dampens out-of-control immune responses, it's being explored as a treatment for other autoimmune diseases such as psoriasis.



http://www.webmd.com/rheumatoid-arthritis/news/20121106/arthritis-drug-xeljanz-fda-approval

New bitaw ni and from my humble observations, effective pod.   

Pwede kaha ni sa akong Gout kay sigi ug ngutngut.

the side effects scare me.  mawa tuod ang kuku sa arthritis, pero mopuli ang ngutngot sa sinusitis?

niundang kog kaon ug baboy ug manok, naaswang na kog kaon ug salmon karon (nga purya kamahal diri sa ato, mantinir na lang kog ulo ug salmon ug panagsaan na lang ang salmon sashimi), naarang-arang man ang ngutngot sa akong joints, vrglguaps.  wa hinoon ko kahibawo kun gout ba ni...

Quote from: vrglguapo on August 05, 2013, 01:27:54 PM
Pwede kaha ni sa akong Gout kay sigi ug ngutngut.

Pwede ni iparelieve sa pain associated with your hyperuricemia. Gout (hyperuricemia) manifests, Nong, kai taas ra kaajo ang uric acid sa dugo. Ug gusto galing ka ma wa na ang sakit, you have to reduce uric acid intake (pork, beef, beans etc are rich in uric acid).

To relieve gout:
1. Modify your uric acid intake
2. Allopurinol and/or Colchicine


Regards!

Quote from: islander on August 05, 2013, 01:33:45 PM
the side effects scare me.  mawa tuod ang kuku sa arthritis, pero mopuli ang ngutngot sa sinusitis?

mao lageh, these are just some of the documented side effects. for those who have arthritis that is refractory to other modes of pharmacotherapy, this new drug can be beneficial.

however, one thing that alarms me is the liver enzyme effects. liver function tests should be regularly checked when taking this drug. that said, patients with liver failure should be dissuaded from taking this.

Quote from: Lorenzo on August 05, 2013, 02:48:05 PM
Pwede ni iparelieve sa pain associated with your hyperuricemia. Gout (hyperuricemia) manifests, Nong, kai taas ra kaajo ang uric acid sa dugo. Ug gusto galing ka ma wa na ang sakit, you have to reduce uric acid intake (pork, beef, beans etc are rich in uric acid).

To relieve gout:
1. Modify your uric acid intake
2. Allopurinol and/or Colchicine


Regards!

Why do we prescribe allopurinol / colchicine?

A: Colchicine is given because it is a tubulin inhibitor and thus directly reduce microtubule buildup seen in gouty arthritis. Allopurinol effectively (directly) reduces uric acid in the blood.

A2: Despite the benefits of these drugs, the best way to augment this is to reduce intake of foods rich in uric acid. (hinay-e lang ang kaon sa baboy , baka, og monggo!...pwede mag tisting tisting gamay...'jaw lang pag habhab)

Wala na jud ko kaon karni puro gulay na lang panagsaan ug manok. Hadlok ko sigi inom difene.

My dad has gout as well, and I'm always reminding him to lay off the mani and monggo kai mao na ijang paborito. Okey mo kaon, so long as in moderasyon lang. Mo inom man si daddy og allopurinol now before he eats anything rich in protein.

Remind nako sija kai di ko gusto maka dungog nga nag sakit ijang tuhod.

Nong Virgil, you can take allopurinol prophylactically (pre-emptive) so that way og mo kaon ka'g karni, di mo flare up ang gouty arthritis.