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Wilms' Tumor:

Most common renal malignancy of early childhood (ages 2-4). Presents with huge, palpable flank mass and/or hematuria. Maybe associated with hemihypertophy syndromes

Contains embronic glomerular structures.

Cause: Deletion of tumor suppressor gene WTI on Chromosome 11.

Note: Can be part of WAGR Complex: Wilm's tumor, aniridia, genitourinary malformation, mental-motor retardation