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By combining glucose and ketone on a single implantable sensor, PercuSense aims to reduce the risk of diabetic ketoacidosis, reducing the burden and ultimately increasing the treatment options for people with diabetes.

VALENCIA, CALIF. (PRWEB) NOVEMBER 02, 2020
PercuSense, an intelligent biosensor and digital health company, announced it has been awarded a $2.5 million program-related investment in the form of a loan from The Leona M. and Harry B. Helmsley Charitable Trust. PercuSense will use the funding to continue development on its novel continuous monitoring system that measures both glucose and ketones on a single minimally invasive probe. PercuSense will also support the University of Melbourne’s efforts to conduct pre-clinical testing and the first-in-human clinical studies, funded through a separate grant from Helmsley.
Diabetic ketoacidosis (DKA) is a potentially life-threatening increase in ketone levels in people with diabetes, which results in over 200,000 hospitalizations and over $5 billion in healthcare expenditure in the U.S. annually. Additionally, SGLT2 inhibitors, a promising class of glucose lowering drugs that offer additional health benefits for people with diabetes, have not yet been FDA-approved for type 1 diabetes in part because they have been shown to increase the risk of DKA in type 1 diabetes. Successful development of PercuSense’s continuous glucose and ketone monitoring system could decrease the risk of DKA and allow for more people with type 1 diabetes to reap the benefits of SGLT2 inhibitors.
With the proper information and early warning, people with diabetes can intervene early to address the underlying cause and help prevent dangerous progression and hospitalization due to DKA. Many people with diabetes are not aware when their ketone levels might be increasing, and because DKA is infrequent, they often do not have easy access to a blood ketone meter. PercuSense’s sensor system will be designed to alert users of increasing ketone levels and continue to monitor these levels after intervention. The system combines the benefits of continuous glucose monitoring while adding the safeguard of continuous ketone monitoring, which does not exist in any current commercial product.
“DKA is a constant, lurking risk for every person living with type 1 diabetes, regardless of whether they have been managing diabetes for ten days or ten years, and even more of a concern for those using or considering SGLT2 inhibitors. A system that can provide both continuous glucose and ketone monitoring (CGKM) can remove this danger, reducing the mental burden and improving the lives of people with type 1 diabetes. Our hope is that CGKM will be the standard of care in the future, and we are excited to support PercuSense’s work in this area.”
– Sean Sullivan, PhD, Type 1 Diabetes Program Officer, Helmsley Charitable Trust
The award builds off of the University of Melbourne and PercuSense’s foundational work developing and testing a continuous ketone sensor system for human feasibility studies, which was funded by a grant from Helmsley to the University of Melbourne. The sensor will employ PercuSense’s novel sensor platform technology that enables low cost, continuous measurement of multiple parameters inside the body.
PercuSense will develop the technology and complete first-in-human testing in collaboration with Dr. David O’Neal and the University of Melbourne.
“PercuSense is honored and excited to be selected by the Helmsley Charitable Trust to continue this important development program. We believe that expanding continuous monitoring beyond glucose for people with diabetes will help prevent DKA, increase peace of mind, and ultimately reduce the daily burden of managing diabetes.”
– Brian Kannard, CEO, PercuSense
About PercuSense
PercuSense is focused on developing next generation continuous sensing platforms that enable prediction, intervention, and prevention in chronic diseases and acute conditions including diabetes management and in-hospital monitoring. PercuSense’s unique technology enables low-cost monitoring of a variety of analytes, including glucose, lactate, oxygen, and ketones, to bring affordable and actionable continuous monitoring to the market. PercuSense’s vision is to provide the right information in the right moment in order to improve outcomes, cost, and burden in settings and diseases across the healthcare spectrum. For more information, please visit percusense.com.
About The Helmsley Charitable Trust
The Leona M. and Harry B. Helmsley Charitable Trust aspires to improve lives by supporting exceptional efforts in the U.S. and around the world in health and select place-based initiatives. Since beginning active grantmaking in 2008, Helmsley has committed more than $2.5 billion for a wide range of charitable purposes. The Helmsley Type 1 Diabetes Program is one of the largest private foundation funders of T1D in the nation, focused on understanding the disease, developing better treatments, and improving care and access. For more information on Helmsley and its programs, visit http://www.helmsleytrust.org.
For inquiries, please contact Brian Kannard at [email protected] or (661) 425-7015.




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