Elizabeth Edwards, the wife of former presidential candidate John Edwards, has died after a battle with breast cancer, a family spokesperson has said.
Mrs Edwards' doctors announced on Monday that further treatment would be unproductive and that she might only have months to live.
Mr Edwards and his wife separated in January after revelations he had fathered a child during an affair.
Mr Edwards ran for the Democratic presidential nomination in 2008.
Mrs Edwards, 61, was first diagnosed with cancer in 2004. The disease then went into remission until the 2008 presidential campaign.
Mr Edwards declined to withdraw from the race until effectively forced out by Hillary Clinton and Barack Obama months later.
"Today we have lost the comfort of Elizabeth's presence, but she remains the heart of this family," her family said in a statement.
"We love her and will never know anyone more inspiring or full of life. On behalf of Elizabeth, we want to express our gratitude to the thousands of kindred spirits who moved and inspired her along the way. Your support and prayers touched our entire family." - BBc
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