Author Topic: So small, yet so complex  (Read 1211 times)

Lorenzo

  • SUPREME COURT
  • THE LEGEND
  • *****
  • Posts: 54226
  • Be the change you want to see in the world...
    • View Profile
So small, yet so complex
« on: February 01, 2008, 05:12:13 AM »
Right now I'm in lab working to prepare slides for students for next week's session, while I was preparing the electron microscope earlier, checking out a particular DNA polymerase of the synthesized E. coli, I realized how so small and complex this little aspect of our genetic backbone. This little speck that is know as the DNA polymerase I is rather interesting because it is a basic 102-kD polypeptide chain and rather versatile, but it catalyzes three quite distinct reactions, that by our standards, seems miniscule, but without it we would be genetically and phenotypically dysfunct. This little Polymerase has two different exonuclease activites, one which is a 3' --> 5', and a 5'--> 3'.

You might ask yourself why does it have two activities? Why was it designed and pre-programmed to have two directionals (bi-directionality)?

Simple. The 3'-->5' activity is important in proofreading newly synthesized DNA, If polymerase I just added the wrong nucleotide to a growing DNA chain, this nucleotide will not base-pair properly with its partner in the parental strand and should be removed. Accordingly, polymerase I pauses and the 3'-->5' exonuclease removes the mispaired nucleotide, allowing replication to continue. This greatly increases the fidelity, or accuracy of the DNA synthesis. Whoever programmed the proofreading ability of Pol I, is brilliant, because without it, error and mutation in the genetic strand would increase 10,000 fold. Amazing isn't it?

The 5'-->3' exonuclease activity allows polymerase I to degrade a strand ahead of the advancing polymerase, so it can remove and replace a strand all in one pass of the polymerase, at least in vitro. This DNA degradation function is useful because polymerase I seems to be involved primarily in DNA repair (including removal and replacement of RNA primers), for which destruction of damaged or mispaired DNA and its replacement by good DNA is required.

I am in absolute and total awe at the brilliance of the creator, who designed  something so infinitely complex, yet make it appear so simple, and make it 'microscopic';  that this 'program' is a a thousand times smaller than the size of a pea. And even with the knowledge we scientists have today, we have come to grasp with about 5% of what there is to know in the genetic complex. Our God, is truly, absolutely, and totally a Brilliant Master. It took man two thousand years to come to grip with with the basics of his creations, eons before we even came to be, these same processes were in full array.

How Great Thou Art, O Lord.

Truly, by unraveling your mysteries, we Glorify thy unassailable Brilliance.


Linkback: https://tubagbohol.mikeligalig.com/index.php?topic=9109.0
www.trip.com - Hassle-free planning of your next trip

unionbank online loan application low interest, credit card, easy and fast approval

Lorenzo

  • SUPREME COURT
  • THE LEGEND
  • *****
  • Posts: 54226
  • Be the change you want to see in the world...
    • View Profile
Reply: So small, yet so complex
« Reply #1 on: February 01, 2008, 05:24:40 AM »
Behold, the true miraculous brilliance of Our Lord.


The DNA strand, the helicase, the okizaki fragments, the tow strand, the ligase, the primers, the lagging and leading strands, continuous and discontinuous strands.

This is what we are. All of Humanity, is nothing but a DNA strand.

Many question the existence of God, science proves his very existence. Many say science disproves religion, I say those who say that are simple minded and blind. Even the absolute nature of science can be defeated, science is merely the accumulation of natural facts, it is never 'constant', science changes, evolution is a manifestation of that. Phenotypes change, promoters change, genetic strands adapt and mold in response to changes in environment, thus there is evolution. One thing is for sure is that no matter what, genetic changes follows a law: base pairs will bond to polypeptides and sugars with complementary charges. Molecular biologists are puzzled by this because we dont know WHY they do this, why some things jut happen, all we know is that it does. There is an unknown force in science, that dictates why things occur, everything is pre-programmed. Its extremely humbling to know that. So whenever you come into contact with an individual who claims he is an aethiest and claims that science 'defeated' God, you can answer him, "No. Science only proves there is a God"


The Brilliance of Our Lord God, those who refuse to believe in God, are foolish and simple minded.
He Makes HIMself known everyday, every minute, every second, every million-th of a second, every time your RNA primers attach to the leading strand, every time your DNA unwinds and replicates, it is God in all of His Wonders.

From the sprouting of  leaf on a spring morning, to birth of a calf, He is Around us Always. Take the time to listen to him, hear him, understand him, and Glorify Him.



Linkback: https://tubagbohol.mikeligalig.com/index.php?topic=9109.0
www.trip.com - Hassle-free planning of your next trip

Julai

  • INTERN
  • **
  • Posts: 662
  • I'm finally free!:)
    • View Profile
Reply: So small, yet so complex
« Reply #2 on: February 01, 2008, 06:05:50 AM »
hi dong bran, thanks for sharing your day in the lab and your insights. I remembered my college days upon reading your stories. I'm familiar of the terms you are using (polymerase, DNA,etc), but the knowledge is already buried deep within. In short, natay an na ahong utok.huhuhuh..

I do agree with you Dong, Science only proves the existence of God. Our professors in college thought us the different theories of the beginning of life here on earth. But among all those, I only believe in the theory of Creation where God authored everything. Though I believed that evolution exists, but it's facilitated by God and that's the very reason why everything turns out right. If God didn't facilitate evolution, then like you said, something will go wrong. Indeed, God is the unknown force in Science.


Linkback: https://tubagbohol.mikeligalig.com/index.php?topic=9109.0
I want to live by the moment and worry no more about my future because I know that God has already made the best plan for me. All I have to do is be faithful to HIM all the time. GOD rocks!

unionbank online loan application low interest, credit card, easy and fast approval

Lorenzo

  • SUPREME COURT
  • THE LEGEND
  • *****
  • Posts: 54226
  • Be the change you want to see in the world...
    • View Profile
Reply: So small, yet so complex
« Reply #3 on: February 01, 2008, 06:19:10 AM »
Juls, you are truly a beautiful mind, and person for your views.
I whole-heartily agree with you, I don't believe in chaos theory or the concept of 'random chance' as what many of my colleagues do. This is where I differ from my contemporaries, they believe in their own glory and the brilliance of Man. Man, to them, is the apex of all that is life, our ability to digest information, create the concepts of science, history, politics, the dictums of knowledge that has been accumulated. Their belief is that life everlasting is not in the form of divine supplication with the Almighty, but by the form of immortality in history. Man is nothing. We did not make anything, man can only manipulate nature, and science is our way of understanding the truth. Random chance or divine influence? You know where I stand on this.

:)

Cheers, Juls

Linkback: https://tubagbohol.mikeligalig.com/index.php?topic=9109.0
www.trip.com - Hassle-free planning of your next trip

Julai

  • INTERN
  • **
  • Posts: 662
  • I'm finally free!:)
    • View Profile
Reply: So small, yet so complex
« Reply #4 on: February 01, 2008, 07:04:33 AM »
That's the problem with some. After God has given them everything, they thought that they're already powerful and that they can already do things without HIS guidance, which is completely wrong. I don't believe in random chance too because the complexities of our DNA's and all other complicated things is never a result of random chance. As what you've said earlier, God has pre-rpgrammed everything and has given mankind the wisdom and intellect to discover their complexities to understand them more.

Cheers to our beliefs dong bran. stay good all the time.

Linkback: https://tubagbohol.mikeligalig.com/index.php?topic=9109.0
I want to live by the moment and worry no more about my future because I know that God has already made the best plan for me. All I have to do is be faithful to HIM all the time. GOD rocks!

Lorenzo

  • SUPREME COURT
  • THE LEGEND
  • *****
  • Posts: 54226
  • Be the change you want to see in the world...
    • View Profile
Reply: So small, yet so complex
« Reply #5 on: February 01, 2008, 08:04:20 AM »
Amen, Juls.

You know the problem with many scientists is Pride, I admit that I myself am tangled in it whenever it comes with work and in research, when one is left in the laboratory for hours in research, the mind is too busy digesting and contemplating all that was learned, one then believes they are greater than others due to their accumulated knowledge. This is where the sense of false superiority comes into place. The devil plays with all of us, Juls, and I do believe in his presence in our world. He provides us with the setting to question our own faith, even the most pious of us question faith at times (I myself am not perfect, am far from perfect, and I will admit that there are times that I question my faith, or times when I despair) the devil plays with us and tries to trick us that we can in fact become gods. I have met countless of great minds in my field, from attending countless biology seminars and graduate seminars, there are biologists that see themselves as somewhat god-like, specially those whose written works and research precedes them in the field of academia.

However, it is ironic that though they enjoy pride and enlightened knowledge now, everything that they have learned and molded with their hands for the benefit of Human knowledge will come and go. Though they see themselves as divine, their bodies will not, in fact their bodies will follow the natural flow of things, their genetic band that allows genetic translation, transcription and replication will weaken with age and as a result, genetic mutanogenesis will occur, as a result causing ill-effects in phenotype as in malformation of red blood cells (sickle cell anemia), the deterioration of their neural synapses and thereby preventing proper neuroelectric impuses from traveling downt he blood-brain barrier, hence a manifestation of memory loss, failure in memory retrieval, because God made it so, their obicularis oris and the obicularis oculi will loosen and as a result eye sight and ability to focus the ocular lens will fade, as age takes its course. The osteoblasts and osteoclasts within their bones will fail to form and retain calcification, and as a result bone loss will manifest (osteoporosis, etc). All of these, though understood by man through science, cannot be fully reversed by science (not by the current standards of treatment we have in place), the very great scientists whose pride claim them as gods cannot reverse the natural flow of aging. They, as man and a creation of the Creator, so too must follow suite in what was dictated by the creator. As our genes replicate, as our cells are created and die, so too must we. We are not different, only a larger sentient form of the organelles that compose our billions of cells, which compose us.

God has willed it so. Life, and death, it is absolute.

Then again I see this symbiosis as a test, that God allows us to be tested by the devil.
It is our ability, as scientists--and privileged with the intelligence we have--to transcend and accept that there truly is a life after this physical state. As cells die, and are eventually phagocytized by leukocytes of the immune system, they become part of the greater body. So too must we, become part of the greater body that is Christ, in union with the Father and the Holy Spirit. He tests our faith, and Heprovides us with the free will to either accept or reject the salvation that He offers.

Linkback: https://tubagbohol.mikeligalig.com/index.php?topic=9109.0
www.trip.com - Hassle-free planning of your next trip

Lorenzo

  • SUPREME COURT
  • THE LEGEND
  • *****
  • Posts: 54226
  • Be the change you want to see in the world...
    • View Profile
Reply: So small, yet so complex
« Reply #6 on: February 01, 2008, 08:16:42 AM »
You know, it is amazing that there's widespread belief that there's a conflict between science and religion. In my personal opinion, this is not true. There may be a conflict between soft-minded religionists and tough-minded scientists, but not between science and religion. Their respective worlds are different and their methods are dissimilar. Science investigate; religion interprets. Science gives man knowledge which is power; religion gives man wisdom which is control. Science deals mainly with facts; religion deals with mainly values. The two are not rivals, in my  personal opinion, they are complementary. Science keeps religion from sinking into the valley of crippling irrationalism and paralyzing obscurantism. Religion prevents science from falling into the marsh of obsolete materialism and moral nihilism.

In the end, it is a test of faith.

[mp3tube]002d5944e7d05bcda82e457ca0c4d3ee[/mp3tube]

Linkback: https://tubagbohol.mikeligalig.com/index.php?topic=9109.0
www.trip.com - Hassle-free planning of your next trip

unionbank online loan application low interest, credit card, easy and fast approval

Tags: